Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation
نویسندگان
چکیده
منابع مشابه
Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology
Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug discovery. Recent years have seen an explosion of interest in developing small molecules binding to bromodomains, the readers of acetyl-lysine modifications. A plethora of co-crystal structures has motivated focused fragment-based design and optimization programs within both industry and academia. These eff...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2019
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201812164